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Broad Protection Against Clade 1 Sarbecoviruses After a Single Immunization with Cocktail Spike-Protein-Nanoparticle Vaccine

2023-06-29

Abstract excerpt

<title>Abstract</title> <p>The 2002 SARS outbreak, the 2019 emergence of COVID-19, and the continuing evolution of immune-evading SARS-CoV-2 variants together highlight the need for a broadly protective vaccine against ACE2-utilizing sarbecoviruses. While updated variant-matched formulations such as Pfizer-BioNTech’s bivalent vaccine are a step in the right direction, protection needs to extend beyond SARS-CoV-2...

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Literature Corpus work
5dafd227-b937-57b5-a972-25eb8e4c5200
DOI
10.21203/rs.3.rs-3088907/v1
Open publication

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