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Single immunization with recombinant ACAM2000 vaccinia viruses expressing the spike and the nucleocapsid proteins protect hamsters against SARS-CoV-2 caused clinical disease

2021-12-03

Abstract excerpt

<h4>SUMMARY</h4> Increasing cases of SARS-CoV-2 breakthrough infections from immunization with predominantly spike protein based COVID-19 vaccines highlight the need for alternative vaccines using different platforms and/or antigens. In this study, we expressed SARS-CoV-2 spike and nucleocapsid proteins in a novel vaccinia virus ACAM2000 platform (rACAM2000). Following a single intramuscular immunization, the rAC...

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Literature Corpus work
5fb016f5-8bd5-5c9d-bf7d-07fe3cfaeb88
DOI
10.1101/2021.12.02.470987
Open publication

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Single immunization with recombinant ACAM2000 vaccinia viruses expressing the spike and the nucleocapsid proteins protect hamsters against SARS-CoV-2 caused clinical diseaseDOI 10.1101/2021.12.02.470987
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