Article

FastCAR: Fast Correction for Ambient RNA to facilitate differential gene expression analysis in single-cell RNA-sequencing datasets

2022-07-20

Abstract excerpt

Cell type-specific differential gene expression analyses based on single-cell transcriptome datasets are sensitive to the presence of cell-free mRNA in the droplets containing single cells. This so-called ambient RNA contamination may differ between samples obtained from patients and healthy controls. Current ambient RNA correction methods were not developed specifically for single-cell differential gene expressio...

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Literature Corpus work: 5dae2526-c086-516b-9051-5a09dbc872f6
DOI: 10.1101/2022.07.19.500594

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