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Article

Exploring the parity paradox: Differential effects on neuroplasticity and inflammation by APOEe4 genotype at middle age.

Brain, behavior, and immunity - 1 Aug 2024

Lee Bonnie H, Cevizci Melike, Lieblich Stephanie E, Ibrahim Muna, Wen Yanhua, Eid Rand S, Lamers Yvonne, Duarte-Guterman Paula, Galea Liisa A M

Abstract excerpt

Female sex and Apolipoprotein E (APOE) ε4 genotype are top non-modifiable risk factors for Alzheimer's disease (AD). Although female-unique experiences like parity (pregnancy and motherhood) have positive effects on neuroplasticity at middle age, previous pregnancy may also contribute to AD risk. To explore these seemingly paradoxical long-term effects of parity, we investigated the impact of parity with APOEε4...

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Identifiers

PMID: 38772427
DOI: 10.1016/j.bbi.2024.05.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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