Article

FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells

2013-10-10

Abstract excerpt

The inability of targeted BRAF inhibitors to produce long-lasting improvement in the clinical outcome of melanoma highlights a need to identify additional approaches to inhibit melanoma growth. Recent studies have shown that activation of the Wnt/β-catenin pathway decreases tumor growth and cooperates with ERK/MAPK pathway inhibitors to promote apoptosis in melanoma. Therefore, the identification of Wnt/β-catenin...

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Literature Corpus work: 5d64b01e-c176-5bc6-a986-e762fc2ac403
DOI: 10.12688/f1000research.2-134.v2

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