Article

A spatially resolved single cell proteomic atlas of Small Bowel Adenocarcinoma

2025-02-04

Abstract excerpt

Small bowel adenocarcinoma (SBA) is a rare malignancy marked with a poor prognosis. The cellular and proteomic heterogeneity within the tumor immune microenvironment (TIME) of SBA is a likely driver of prognosis, disease progression and response to therapy. We have addressed a major gap in knowledge of the TIME in SBA using highly multiplexed, protein imaging of the SBA tumor-immune ecosystem generating a comprehe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d2a739a-c58e-58b9-a128-d2d0c9f50faf
DOI: 10.1101/2025.02.01.634535

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A spatially resolved single cell proteomic atlas of Small Bowel AdenocarcinomaDOI 10.1101/2025.02.01.634535Read

Revisiting the immune microenvironment of human colorectal cancer in the era of single-cell and spatial omicsSemantic proximity Read

High-definition spatial transcriptomic profiling of immune cell populations in colorectal cancerSemantic proximity Read

Characterization of immune cell populations in the tumor microenvironment of colorectal cancer using high definition spatial profilingSemantic proximity Read

Integrative Transcriptomic and Single-Cell Protein Characterization of Colorectal Carcinoma Delineates Distinct Tumor Immune Microenvironments Associated with Overall SurvivalSemantic proximity Read

Deep immunophenotyping reveals clinically distinct cellular states and ecosystems in large-scale colorectal cancerSemantic proximity Read

A Single-Cell Tumor Immune Atlas for Precision OncologySemantic proximity Read

Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancerSemantic proximity Read

A Pan-cancer Blueprint of the Heterogeneous Tumour Microenvironment Revealed by Single-Cell ProfilingSemantic proximity Read

Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancerSemantic proximity Read

Comprehensive molecular portrait reveals genetic diversity and distinct molecular subtypes of small intestinal neuroendocrine tumorsSemantic proximity Read

Single‐cell transcriptome analysis revealed the heterogeneity and microenvironment of gastrointestinal stromal tumorsSemantic proximity Read

Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive FrontSemantic proximity Read