Article

Treatment with 2-phospho-L-ascorbic acid mitigates biochemical phenotypes of heme oxygenase 1 deficiency

2024-07-07

Abstract excerpt

<h4>ABSTRACT</h4> Heme oxygenase 1 (HO-1) deficiency is a fatal genetic disorder characterized by impaired heme catabolism, leading to excessive oxidative damage and cell death. Despite evidence from non-human models suggesting mitochondrial dysfunction, the precise pathomechanisms in humans remain unclear, resulting in a lack of effective treatments. Using patient-derived lymphoblastoid cells and HO-1 knockout H...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d269ede-9eb7-530a-8ff9-6cfac9e3432f
DOI: 10.1101/2024.07.05.602073

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Treatment with 2-phospho-L-ascorbic acid mitigates biochemical phenotypes of heme oxygenase 1 deficiencyDOI 10.1101/2024.07.05.602073Read

Ascorbic Acid Therapy in Hematological Malignancies - The Current Knowledge and Future DirectionsSemantic proximity Read

Chemical Transport Knockout for Oxidized Vitamin C, Dehydroascorbic Acid, Reveals Its Functions in vivo.Semantic proximity Read

Vitamin C induced hemolysis: Meta summary and review of literatureSemantic proximity Read

Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the EvidenceSemantic proximity Read

Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia.Semantic proximity Read

The vitamin K oxidoreductase VKORC1L1 prevents oxidative stress in hepatocytes and protects from MASLD and hepatocellular carcinomaSemantic proximity Read

High-dose IV ascorbic acid therapy for patients with CCUS with TET2 mutations.Semantic proximity Read

Hypocatalasemic Fibroblasts Accumulate Hydrogen Peroxide and Display Age‐Associated PathologiesSemantic proximity Read

High-dose Vitamin C Blocks HOCl Production by Myeloperoxidase: A Potential Therapeutic StrategySemantic proximity Read

Molecular Basis for the Interaction of Catalase with D-Penicillamine : Rationalization of some of its Deleterious EffectsSemantic proximity Read

Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expressionSemantic proximity Read

DMT1-mutant erythrocytes have shortened life span, accelerated glycolysis and increased oxidative stress.Semantic proximity Read