Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia.

Journal of pediatric hematology/oncology - 1 Jan 2011

Radhakrishnan Nita, Yadav Satya Prakash, Sachdeva Anupam, Pruthi Praveen K, Sawhney Sujata, Piplani Tarun, Wada Taizo, Yachie Akihiro

Abstract excerpt

Heme oxygenase-1 (HO-1) is a stress-induced enzyme that catalyses the oxidation of heme to biliverdin. The primary deficiency of this enzyme has been shown in HO-1 knockout mice, and is characterized by intrauterine death and chronic inflammation. The first case of human HO-1 deficiency was reported in 1999. Human HO-1 deficiency has been observed to involve the endothelial cells more severely, resulting in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Heme Oxygenase-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemolysis

Share to Inflammation

Share to Mutation

Share to Nephritis

Share to Spleen

Source

Identifiers

PMID: 21088618
DOI: 10.1097/MPH.0b013e3181fd2aae

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia.PMID 21088618Read ↗

Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flaresSemantic proximity Read ↗

Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flaresSemantic proximity Read ↗

An Atypical Case of Atypical Hemolytic Uremic Syndrome.Semantic proximity Read ↗

An interesting tetrad of asplenia, inflammation, hemolysis, and nephritis.Semantic proximity Read ↗

Fetal-onset Congenital Dyserythropoietic Anemia Type 1 due to a Novel Mutation With Severe Iron Overload and Severe Cholestatic Liver Disease.Semantic proximity Read ↗

Oxygen sensing: recent insights from idiopathic erythrocytosis.Semantic proximity Read ↗

Clinical Characteristics of Pediatric Patients with Congenital Erythrocytosis: A Single Center StudySemantic proximity Read ↗

An Infant with Severe Anemia and Hypoalbuminemia.Semantic proximity Read ↗

Recurrent Infections and Immunodeficiency Caused by Severe Pancytopenia Associated with a Novel Life-Threatening Mutation in Hypoxia-Upregulated Protein 1.Semantic proximity Read ↗

Nonimmune Anemias.Semantic proximity Read ↗

Fetal presentation of congenital dyserythropoietic anemia type 1 with novel compound heterozygous CDAN1 mutations.Semantic proximity Read ↗

Anemia in the Neonate: The Differential Diagnosis and Treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.