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Article

An Alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Development

2 Sept 2010

Abstract excerpt

Fetal trophoblast cells invading the decidua in the early phase of pregnancy establish complex interaction with the maternal extracellular matrix. We discovered that C1q was widely distributed in human decidual stroma in the absence of C4 and C3 and was actively synthesized by migrating extravillous trophoblasts. The cells expressed the messages for the three chains of C1q and secreted this complement component...

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Share to Blood Coagulation and Thrombosis Mechanisms
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PMID: 20810993
DOI: 10.4049/jimmunol.0903215

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