Article

Determining mutational burden and signature using RNA-seq from tumor-only samples

2021-01-21

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Traditionally, mutational burden and mutational signatures have been assessed by tumor-normal pair DNA sequencing. The requirement of having both normal and tumor samples is not always feasible from a clinical perspective, and led us to investigate the efficacy of using RNA sequencing of only the tumor sample to determine the mutational burden and signatures, an...

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Literature Corpus work: 5d036360-6b67-5034-8f3c-fa26e2fd4ea1
DOI: 10.21203/rs.2.21641/v3

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