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Article

Determining mutational burden and signature using RNA-seq from tumor-only samples.

BMC medical genomics - 1 Mar 2021

Jessen Erik, Liu Yuanhang, Davila Jaime, Kocher Jean-Pierre, Wang Chen

Abstract excerpt

BACKGROUND: Traditionally, mutational burden and mutational signatures have been assessed by tumor-normal pair DNA sequencing. The requirement of having both normal and tumor samples is not always feasible from a clinical perspective, and led us to investigate the efficacy of using RNA sequencing of only the tumor sample to determine the mutational burden and signatures, and subsequently molecular cause of the...

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Identifiers

PMID: 33648520
DOI: 10.1186/s12920-021-00898-y
PMCID: PMC7923324

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