Copy number variation and neuropsychiatric illness.

Abstract excerpt

Copy number variants (CNVs) at specific loci have been identified as important risk factors for several neuropsychiatric disorders, such as schizophrenia, autism spectrum disorder, intellectual disability (ID) and depression. These CNVs are individually rare (<0.5% frequency), have high effect sizes, and show pleiotropic effects for multiple neuropsychiatric disorders, which implies a shared aetiology....

Topics

• DNA Copy Number Variations
• Gene Deletion
• Gene Duplication
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Humans
• Mental Disorders
• Whole Genome Sequencing