Article
Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats.
Carcinogenesis - 1 Jun 2006
Pogribny Igor P, Ross Sharon A, Tryndyak Volodymyr P, Pogribna Marta, Poirier Lionel A, Karpinets Tatiana V
Abstract excerpt
The field of cancer epigenetics has received much attention in recent years. However, the relationship of cancer epigenetics with cancer etiology is not clear. Recent studies suggest the involvement of altered DNA methylation and histone modifications in the emergence of epigenetically reprogrammed cells with specific tumor-related phenotypes at premalignant stages of tumor development. In this study, we used a...
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