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Article

<i>In vivo</i> CGG repeat RNA binding protein capture identifies RAN translation modifiers and suppressors of repeat toxicity

2021-01-09

Abstract excerpt

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a transcribed CGG repeat expansion in the 5’ UTR of FMR1 . Expanded CGG repeat RNAs both sequester RNA-binding proteins (RBPs) into nuclear foci and undergo repeat-associated non-AUG (RAN) translation into toxic homopolymeric peptides. RBPs that interact with CGG repeats may play a pivotal role in foci formation and/or R...

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Literature Corpus work
7edf901e-c52d-5c12-a041-0cf4d21305ea
DOI
10.1101/2021.01.08.425998
Open publication

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<i>In vivo</i> CGG repeat RNA binding protein capture identifies RAN translation modifiers and suppressors of repeat toxicityDOI 10.1101/2021.01.08.425998
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