Article
GBA Variants Influence Motor and Non-Motor Features of Parkinson's Disease.
PloS one - 1 Jan 2016
Jesús Silvia, Huertas Ismael, Bernal-Bernal Inmaculada, Bonilla-Toribio Marta, Cáceres-Redondo María Teresa, Vargas-González Laura, Gómez-Llamas Myriam, Carrillo Fátima, Calderón Enrique, Carballo Manuel, Gómez-Garre Pilar, Mir Pablo
Abstract excerpt
The presence of mutations in glucocerebrosidase (GBA) gene is a known factor increasing the risk of developing Parkinson's disease (PD). Mutations carriers have earlier disease onset and are more likely to develop neuropsychiatric symptoms than other sporadic PD cases. These symptoms have primarily been observed in Parkinson's patients carrying the most common pathogenic mutations L444P and N370S. However, recent...
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