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Article

Association between heterozygous GBA1 L444P carrier status and risk of Parkinson's disease: A systematic review and meta-analysis.

Molecular genetics and metabolism - 1 Jun 2026

Jurecka Agnieszka, Kim Hyun Kyung, Siegfried Noelle, Zhao Yu Chen

Abstract excerpt

INTRODUCTION AND OBJECTIVE: Mutations in the GBA1 gene, particularly the severe L444P variant, are among the strongest known genetic risk factors for Parkinson's disease (PD). Prior meta-analyses published before 2018 included fewer studies and often pooled multiple mutations, prompting this updated, mutation-specific systematic review and meta-analysis. METHODS: Standard systematic review and meta-analytic...

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Identifiers

PMID: 41936135
DOI: 10.1016/j.ymgme.2026.110112

Genes

GBA1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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