Article

Predominant cellular mitochondrial dysfunction in the TOP3A gene caused Bloom syndrome-like disorder

2020-09-03

Abstract excerpt

<title>Abstract</title> <p>Background TOP3A is a subunit of the BLM-TOP3A-RMI1/2 complex, which promotes processing of double Holliday junction dissolution and also plays an important role in decatenation and segregation of human mtDNA. Recently, <italic>TOP3A</italic> mutations have been reported to cause Bloom syndrome-like disorder. However, whether the two function play equal roles in the disease pathogenesi...

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Literature Corpus work: 5c5798e2-bc06-524c-9f5d-84a179d51810
DOI: 10.21203/rs.3.rs-67767/v1

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