Article

Layered Single-Cell Heterogeneity in Hormone Receptor Signaling Across Mouse Organoids and Human ERα+ Cancer Cells

2026-03-23

Abstract excerpt

<h4>Summary</h4> Hormone receptor signaling is often interpreted through receptor abundance as a proxy for hormone responsiveness, yet the determinants of single-cell variability in hormone response remain unclear. Using murine mammary organoids, we mapped estrogen (E2) and progesterone (P4) responses at single-cell resolution. Despite controlled 3D culture conditions, basal cell-derived organoids exhibit strikin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5c5148b1-47ce-5ec2-9613-4ee0029985de
DOI: 10.64898/2026.03.19.712456

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Layered Single-Cell Heterogeneity in Hormone Receptor Signaling Across Mouse Organoids and Human ERα+ Cancer CellsDOI 10.64898/2026.03.19.712456Read

Single-Cell Transcription Mapping of Murine and Human Mammary Organoids Responses to Female HormonesSemantic proximity Read

Estrogen regulates divergent transcriptional and epigenetic cell states in breast cancerSemantic proximity Read

Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolutionSemantic proximity Read

An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptomeSemantic proximity Read

Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesisSemantic proximity Read

Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancerSemantic proximity Read

Tamoxifen Response at Single Cell Resolution in Estrogen Receptor-Positive Primary Human Breast TumorsSemantic proximity Read

Estrogen Receptor Enhancers Sensitive to Low Doses of Hormone Specify Distinct Molecular and Biological OutcomesSemantic proximity Read

Gene expression in organoids: an expanding horizonSemantic proximity Read

EstroGene database reveals diverse temporal, context-dependent and directional estrogen receptor regulomes in breast cancerSemantic proximity Read

Alternative super-enhancers result in similar gene expression in different tissuesSemantic proximity Read

Deciphering Steroid Receptor Crosstalk in Hormone-Driven CancersSemantic proximity Read