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Article

Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model

1 Jan 2020

Abstract excerpt

Clinical observations suggest that responses to cancer immunotherapy are correlated with intra-tumoral T cell receptor (TCR) clonality, tumor mutation burden (TMB) and host HLA genotype, highlighting the importance of host T cell recognition of tumor antigens. However, the dynamic interplay between T cell activation state and changes in TCR repertoire in driving the identification of potential immunodominant...

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PMID: 32923116
DOI: 10.1080/2162402x.2020.1758602

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