Article

Nuclear Smooth Muscle α-actin in Vascular Smooth Muscle Cell Differentiation

2023-02-28

Abstract excerpt

<title>Abstract</title> <p>Missense variants throughout <italic>ACTA2</italic>, encoding smooth muscle α-actin (αSMA), predispose to adult onset thoracic aortic disease, but variants disrupting arginine 179 (R179) lead to Smooth Muscle Dysfunction Syndrome (SMDS) characterized by childhood-onset diverse vascular diseases. Our data indicate that αSMA localizes to the nucleus in wildtype (WT) smooth muscle cells (S...

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Literature Corpus work: 5c3020ad-0bf2-5ac7-bdf5-d5b4fa95b22a
DOI: 10.21203/rs.3.rs-1623114/v1

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