Article

Pathway-based Rare Variant Burden Analysis Identifies a Role for the Complement System in an Extreme Phenotype of Sepsis with Coagulopathy

2022-02-25

Abstract excerpt

Extreme disease phenotypes have the potential to provide key pathophysiologic insights, but the study of these conditions is challenging due to their rarity and the limited statistical power of existing methods. Herein, we apply a novel pathway-based approach to investigate the role of rare genomic variants in infectious purpura fulminans (PF) 1,2 , an extreme phenotype of sepsis with hyperinflammation and coagulo...

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Literature Corpus work: 5c29867d-1bf3-5880-a26f-91a2d2d789e6
DOI: 10.1101/2022.02.24.22271459

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Pathway-based Rare Variant Burden Analysis Identifies a Role for the Complement System in an Extreme Phenotype of Sepsis with CoagulopathyDOI 10.1101/2022.02.24.22271459Read

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