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Article

Adults with septic shock and extreme hyperferritinemia exhibit pathogenic immune variation.

Genes and immunity - 1 Jul 2019

Kernan Kate F, Ghaloul-Gonzalez Lina, Shakoory Bita, Kellum John A, Angus Derek C, Carcillo Joseph A

Abstract excerpt

Post-hoc subgroup analysis of the negative trial of interleukin-1β receptor antagonist (IL1RA) for septic shock suggested that patients with features of macrophage activation syndrome (MAS) experienced a 50% relative risk reduction for mortality with treatment. Here we seek a genetic basis for this differential response. From 1341 patients enrolled in the ProCESS trial of early goal directed therapy for septic...

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Identifiers

PMID: 29977033
DOI: 10.1038/s41435-018-0030-3
PMCID: PMC6320733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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