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Article

Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis.

Critical care explorations - 1 Nov 2025

Inman Kyle, Chernus Jonathan, Lee Myoungkeun, Alder Jonathan K, Shah Faraaz Ali, Mayr Florian B, Dempsey Timothy, Nouraie S Mehdi, Dela Cruz Charles, Ferreira Viviana P, Kulkarni Hrishikesh S, Meyer Nuala J, Strollo Patrick J, Feingold Eleanor, Bain William

Abstract excerpt

IMPORTANCE: The alternative complement pathway is a key component of host defense against bacteremia and other infections. However, dysregulated activation can contribute to excessive inflammation and worse clinical outcomes during bacteremia and infectious syndromes such as sepsis. OBJECTIVES: We aim to identify variants in alternative pathway (AP) genes that influence the risk for bacteremia and sepsis. DESIGN,...

Topics

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Bacteremia
Complement Pathway, Alternative
Genetic Predisposition to Disease
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Polymorphism, Single Nucleotide

Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 41165296
DOI: 10.1097/CCE.0000000000001339
PMCID: PMC12574529

Genes

C5AR1
CFB
MVP
C5AR2
CFD
CFI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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