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Article

Systematic proteome-wide Mendelian randomization to prioritize causal plasma proteins for skin cancers.

Communications biology - 19 Dec 2024

Yoshikawa Masahiro, Nakayama Tomohiro, Asaba Kensuke

Abstract excerpt

Skin cancer is one of the most common cancers worldwide. Some risk factors including sun exposure and MC1R variants are recognized; however, the identification of additional genetic factors is essential for the development of novel therapeutic strategies. Here, we conducted a proteome-wide Mendelian randomization (MR) using plasma protein quantitative trait loci (pQTLs) from a published study and the UK Biobank...

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Identifiers

PMID: 39702585
DOI: 10.1038/s42003-024-07403-y
PMCID: PMC11659389

Genes

ASIP
CTSS
MC1R

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