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Systematic proteome-wide Mendelian randomization to prioritize causal plasma proteins for skin cancers.

Communications biology - 19 Dec 2024

Yoshikawa Masahiro, Nakayama Tomohiro, Asaba Kensuke

Abstract excerpt

Skin cancer is one of the most common cancers worldwide. Some risk factors including sun exposure and MC1R variants are recognized; however, the identification of additional genetic factors is essential for the development of novel therapeutic strategies. Here, we conducted a proteome-wide Mendelian randomization (MR) using plasma protein quantitative trait loci (pQTLs) from a published study and the UK Biobank...

Topics

Skin Neoplasms
Humans
Mendelian Randomization Analysis
Genome-Wide Association Study
Proteome
Blood Proteins
Quantitative Trait Loci
Melanoma
Basal Cell Carcinoma
Genetic Predisposition to Disease
Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 39702585
DOI: 10.1038/s42003-024-07403-y
PMCID: PMC11659389

Genes

ASIP
CTSS
MC1R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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