Article

3-O-methyltolcapone and Its Lipophilic Analogues are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity

2023-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Transthyretin (TTR) is an amyloidogenic homotetramer involved in the transport of thyroxine in blood and cerebrospinal fluid. To date, more than 130 TTR point mutations are known to destabilise the TTR tetramer, leading to its extracellular pathological aggregation accumulating in several organs, such as heart, peripheral and autonomic nerves, and leptomeninges. Tolcapone is an FDA-approved drug...

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Literature Corpus work: 5c07c850-0985-5be9-9c1f-afc5b22edfe8
DOI: 10.1101/2023.10.25.563927

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