Article
Therapeutic applications of thyroid hormone analogues in resistance to thyroid hormone (RTH) syndromes.
Molecular and cellular endocrinology - 15 Dec 2017
Groeneweg Stefan, Peeters Robin P, Visser Theo J, Visser W Edward
Abstract excerpt
Thyroid hormone (TH) is crucial for normal development and metabolism of virtually all tissues. TH signaling is predominantly mediated through binding of the bioactive hormone 3,3',5-triiodothyronine (T3) to the nuclear T3-receptors (TRs). The intracellular TH levels are importantly regulated by transporter proteins that facilitate the transport of TH across the cell membrane and by the three deiodinating...
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