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Article

Systemic optimization and structural evaluation of quinoline derivatives as transthyretin amyloidogenesis inhibitors.

European journal of medicinal chemistry - 10 Nov 2016

Kim Boyoung, Park Hwanggue, Lee Seul Ki, Park Sung Jean, Koo Tae-Sung, Kang Nam Sook, Hong Ki Bum, Choi Sungwook

Abstract excerpt

Wild type transthyretin (TTR) and mutant TTR misfold and misassemble into a variety of extracellular insoluble amyloid fibril and/or amorphous aggregate, which are associated with a variety of human amyloid diseases. To develop potent TTR amyloidogenesis inhibitors, we have designed and synthesized a focused library of quinoline derivatives by Pd-catalyzed coupling reaction and by the Horner-Wadsworth-Emmons...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27541261
DOI: 10.1016/j.ejmech.2016.08.003

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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