Article

Elevated nuclear TDP-43 induces constitutive exon skipping

2023-05-12

Abstract excerpt

Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-function, TDP-43 overexpression has been used to generate in vitro and in vivo model systems. Our study shows that excessive levels of nuclear TDP-43 protein lead to constitutive exon skipping that is large...

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Literature Corpus work: 5c06398e-5b78-5327-ad54-780d886a6d0a
DOI: 10.1101/2023.05.11.540291

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