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Article

Elevated nuclear TDP-43 induces constitutive exon skipping

9 Jun 2024

Abstract excerpt

BACKGROUND: Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-function, TDP-43 overexpression has been used to generate in vitro and in vivo model systems. METHODS: We analyzed RNA-seq datasets from mouse and human neurons overexpressing TDP-43 to explore...

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PMID: 38853250
DOI: 10.1186/s13024-024-00732-w

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