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Article

Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing.

Nature cell biology - 1 Jun 2018

Gao Shuai, Yan Liying, Wang Rui, Li Jingyun, Yong Jun, Zhou Xin, Wei Yuan, Wu Xinglong, Wang Xiaoye, Fan Xiaoying, Yan Jie, Zhi Xu, Gao Yun, Guo Hongshan, Jin Xiao, Wang Wendong, Mao Yunuo, Wang Fengchao, Wen Lu, Fu Wei, Ge Hao, Qiao Jie, Tang Fuchou

Abstract excerpt

The development of the digestive tract is critical for proper food digestion and nutrient absorption. Here, we analyse the main organs of the digestive tract, including the oesophagus, stomach, small intestine and large intestine, from human embryos between 6 and 25 weeks of gestation as well as the large intestine from adults using single-cell RNA-seq analyses. In total, 5,227 individual cells are analysed and...

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PMID: 29802404
DOI: 10.1038/s41556-018-0105-4

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