Article

A resource-based mechanistic framework for castration-resistant prostate cancer (CRPC)

2023-09-21

Abstract excerpt

Cancer therapy often leads to the selective elimination of drug-sensitive cells from the tumour. This can favour the growth of cells resistant to the therapeutic agent, ultimately causing a tumour relapse. Castration-resistant prostate cancer (CRPC) is a well-characterised instance of this phenomenon. In CRPC, after systemic androgen deprivation therapy (ADT), a subset of drug-resistant cancer cells autonomously p...

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Literature Corpus work: 5beb6ff9-05b6-5275-a2be-65d14651cd28
DOI: 10.1101/2023.09.19.558379

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