Article

Concordance of ALK fusion gene-rearrangement between immunohistochemistry and next-generation sequencing

2023-09-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Although various companion diagnostic tests of <italic>ALK</italic> fusion gene-rearrangement are approved, few reports have assessed the concordance of <italic>ALK</italic> fusion gene-rearrangement in two companion diagnostic tests: next-generation sequencing (NGS) testing and immunohistochemistry (IHC). <bold>Methods:</bold> The samples evaluated for gene alt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5bcfec24-67b6-5d1f-a1ee-91a77591b7ff
DOI: 10.21203/rs.3.rs-3285792/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Concordance of ALK fusion gene-rearrangement between immunohistochemistry and next-generation sequencingDOI 10.21203/rs.3.rs-3285792/v1Read

IHC versus FISH versus NGS to detect ALK gene rearrangement in NSCLC: all questions answered?Semantic proximity Read

Diagnostic impact of RNA-based next-generation sequencing fusion panel for solid tumors: A single-institution experienceSemantic proximity Read

Molecular characteristics and clinical outcomes of complex ALK rearrangements identified by next-generation sequencing in non-small cell lung cancersSemantic proximity Read

Gene rearrangement detection by next-generation sequencing in patients with non-small cell lung carcinoma.Semantic proximity Read

[A consistency comparison between next-generation sequencing and the FISH method for gene rearrangement detection in B-cell lymphomas].Semantic proximity Read

Multicenter evaluation of an automated, multiplex, RNA-based molecular assay for detection of ALK, ROS1, RET fusions and MET exon 14 skipping in NSCLCSemantic proximity Read

Multiplexed transcriptome analysis to detect ALK, ROS1 and RET rearrangements in lung cancerSemantic proximity Read

NTRK Gene Fusions in Non-Small-Cell Lung Cancer: Real-World Screening Data of 1068 Unselected PatientsSemantic proximity Read

Detecting Gene Rearrangements in Patient Populations Through a 2-Step Diagnostic Test Comprised of Rapid IHC Enrichment Followed by Sensitive Next-Generation SequencingSemantic proximity Read

Validation of the Idylla GeneFusion assay to detect fusions and MET exon-skipping in non-small cell lung cancers.Semantic proximity Read

Catalog of 5’ Fusion Partners in ALK-positive NSCLC Circa 2020Semantic proximity Read

Reliability analysis of exonic-breakpoint fusions identified by DNA sequencing for predicting the efficacy of targeted therapy in non-small cell lung cancerSemantic proximity Read