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Article

Validation of the Idylla GeneFusion assay to detect fusions and MET exon-skipping in non-small cell lung cancers.

Scientific reports - 9 Aug 2023

Gilson Pauline, Pouget Celso, Belmonte Richard, Fadil Smahane, Demange Jessica, Rouyer Marie, Lacour Julien, Betz Margaux, Dardare Julie, Witz Andréa, Merlin Jean-Louis, Harlé Alexandre

Abstract excerpt

Gene fusions and MET exon skipping drive oncogenesis in 8-9% and 3% of non-small cell lung cancers (NSCLC) respectively. Their detection are essential for the management of patients since they confer sensitivity to specific targeted therapies with significant clinical benefit over conventional chemotherapy. Immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH) account for historical reference...

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Identifiers

PMID: 37558711
DOI: 10.1038/s41598-023-39749-4
PMCID: PMC10412571

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