Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiplexed transcriptome analysis to detect ALK, ROS1 and RET rearrangements in lung cancer

9 Feb 2017

Abstract excerpt

ALK, ROS1 and RET gene fusions are important predictive biomarkers for tyrosine kinase inhibitors in lung cancer. Currently, the gold standard method for gene fusion detection is Fluorescence In Situ Hybridization (FISH) and while highly sensitive and specific, it is also labour intensive, subjective in analysis, and unable to screen a large numbers of gene fusions. Recent developments in high-throughput...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lung Cancer Research Studies
Share to Lung Cancer Treatments and Mutations
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28181564
DOI: 10.1038/srep42259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiplexed transcriptome analysis to detect ALK, ROS1 and RET rearrangements in lung cancerPMID 28181564Read ↗

Multiplexed Gene Expression and Fusion Transcript Analysis to Detect ALK Fusions in Lung CancerSemantic proximity Read ↗

Simultaneous detection of lung fusions using a multiplex RT-PCR next generation sequencing-based approach: a multi-institutional research studySemantic proximity Read ↗

Clinical framework for next generation sequencing based analysis of treatment predictive mutations and multiplexed gene fusion detection in non-small cell lung cancer.Semantic proximity Read ↗

Detection of gene fusions using targeted next-generation sequencing: a comparative evaluationSemantic proximity Read ↗

High‐throughput diagnostic profiling of clinically actionable gene fusions in lung cancerSemantic proximity Read ↗

Analysis of Fusion Genes by NanoString System: A Role in Lung Cytology?Semantic proximity Read ↗

Multicenter evaluation of an automated, multiplex, RNA-based molecular assay for detection of ALK, ROS1, RET fusions and MET exon 14 skipping in NSCLCSemantic proximity Read ↗

Recurrent and novel fusions detected by targeted RNA sequencing as part of the diagnostic workflow of soft tissue and bone tumoursSemantic proximity Read ↗

RET Fluorescence In Situ Hybridization Analysis Is a Sensitive but Highly Unspecific Screening Method for RET Fusions in Lung CancerSemantic proximity Read ↗

Targeted RNA‐sequencing assays: a step forward compared to FISH and IHC techniques?Semantic proximity Read ↗

A Performance Comparison of Commonly Used Assays to Detect RET FusionsSemantic proximity Read ↗

Integrating the Idylla™ System Alongside a Real-Time Polymerase Chain Reaction and Next-Generation Sequencing for Investigating Gene Fusions in Pleural Effusions from Non-Small-Cell Lung Cancer Patients: A Pilot Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.