Article

The antiviral potential of the antiandrogen enzalutamide and the viral-androgen interplay in seasonal coronaviruses

2023-11-27

Abstract excerpt

The sex disparity in COVID-19 outcomes with males generally faring worse than females has been associated with the androgen-regulated expression of the protease TMPRSS2 and the cell receptor ACE2 in the lung and fueled interest in antiandrogens as potential antivirals. In this study, we explored enzalutamide, an antiandrogen used commonly against prostate cancer, as a potential antiviral against the human coronavi...

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Literature Corpus work: 5b55c92c-36e6-5075-a724-2d9475207dfc
DOI: 10.1101/2023.11.25.568685

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