Article

Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2

2020-04-21

Abstract excerpt

The sex discordance in COVID-19 outcomes has been widely recognized, with males generally faring worse than females and a potential link to sex steroids. A plausible mechanism is androgen-induced expression of TMPRSS2 and/or ACE2 in pulmonary tissues that may increase susceptibility or severity in males. This hypothesis is the subject of several clinical trials of anti-androgen therapies around the world. Here, we...

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Literature Corpus work: 1dd6a1ef-aae0-5e0a-a9b6-a2e121780ebf
DOI: 10.1101/2020.04.21.051201

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