Article
CYP19A1 mediated sex hormone metabolism promotes severe SARS-CoV-2 disease outcome in males.
2021-12-08
Abstract excerpt
<title>Abstract</title> <p> Male sex belongs to one of the major risk factors for severe COVID-19 outcome. However, underlying mechanisms that could affect sex dependent disease outcome are yet unknown. Here, we identified the <italic>CYP19A1</italic> gene encoding for the testosterone-to-estradiol metabolizing enzyme CYP19A1 (alias aromatase) as a male abundant host factor that contributes to worsened disease...
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Identifiers and source
- Literature Corpus work
- 578e20a5-d71f-5ade-87c7-a458c9f7ddc0
- DOI
- 10.21203/rs.3.rs-107474/v2