Article
Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2016
Woerman Amanda L, Aoyagi Atsushi, Patel Smita, Kazmi Sabeen A, Lobach Iryna, Grinberg Lea T, McKee Ann C, Seeley William W, Olson Steven H, Prusiner Stanley B
Abstract excerpt
Tau prions are thought to aggregate in the central nervous system, resulting in neurodegeneration. Among the tauopathies, Alzheimer's disease (AD) is the most common, whereas argyrophilic grain disease (AGD), corticobasal degeneration (CBD), chronic traumatic encephalopathy (CTE), Pick's disease (PiD), and progressive supranuclear palsy (PSP) are less prevalent. Brain extracts from deceased individuals with PiD,...
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