Article

Intrinsic Phenotypic Differences, Not Hemodynamic Shear, Associate with Cusp-Specific Remodeling in Aortic Valve Disease

2025-10-01

Abstract excerpt

Aortic valve disease (AVD) is asymmetric. Various clinical reports indicate that the non- coronary cusp (NCC) is disproportionally burdened by pathological remodeling like inflammation, fibrosis, and calcification. This has long been attributed to the resulting differences in hemodynamic load that arise from the presence, or lack thereof, of coronary ostia in respective sinuses. However, there is little to no empi...

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Literature Corpus work: 5b13c334-8d01-5f85-aa12-bd6ac45e3e31
DOI: 10.1101/2025.09.29.679396

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