Article

Assessing donor-to-donor variability in human intestinal organoid cultures

2021-07-25

Abstract excerpt

<h4>Summary</h4> Donor-to-donor variability in primary human organoid cultures has not been well characterized. As these cultures contain multiple cell types, there is greater concern that variability could lead to increased noise. In this work we investigated donor-to-donor variability in human gut adult stem cell (ASC) organoids. We examined intestinal developmental pathways during culture differentiation in il...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5ac8c5b5-b8b5-5779-bfec-2e1572d07805
DOI: 10.1101/2021.07.23.453590

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Assessing donor-to-donor variability in human intestinal organoid culturesDOI 10.1101/2021.07.23.453590Read

Assessing donor-to-donor variability in human intestinal organoid culturesSemantic proximity Read

Metabolic Studies in Organoids: Current Applications, Opportunities and ChallengesSemantic proximity Read

RNA-sequencing of single cholangiocyte-derived organoids reveals high organoid-to organoid variabilitySemantic proximity Read

Single organoid RNA-sequencing reveals high organoid-to-organoid variabilitySemantic proximity Read

Drivers of Transcriptional Variance in Human Intestinal Epithelial OrganoidsSemantic proximity Read

Characterization and optimization of variability in a human colonic epithelium culture modelSemantic proximity Read

Employing human intestinal organoids as advanced in vitro models for mechanistic studies on dietary ingredientsSemantic proximity Read

Characterization of human mesenchymal stem cells from multiple donors and the implications for large scale bioprocess developmentSemantic proximity Read

Molecular Heterogeneity of Breast Milk in Intestinal Development: A Multi-Omics Approach Using Human Organoids and Caco-2 CellsSemantic proximity Read

Drivers of transcriptional variance in human intestinal epithelial organoidsSemantic proximity Read

Early multi-omic signatures and machine learning models predict cardiomyocyte differentiation efficiency and enable robust hPSC differentiation to cardiomyocytesSemantic proximity Read

Metabolomic Applications in Stem Cell Research: a ReviewSemantic proximity Read