Article

NEK1 modulates neurite outgrowth in motor neurons through coordinating retromer formation

2024-05-08

Abstract excerpt

<h4>SUMMARY</h4> Loss of function of a cell cycle-associated gene NEK1 causes amyotrophic lateral sclerosis (ALS), but how this leads to motor neuron degeneration is unknown. We studied the function of NEK1 in human stem cell-derived motor neurons and found that loss of NEK1 causes decreased neurite length accompanied by transcriptional alterations. We also found that NEK1 interacts with and modulates the form...

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Literature Corpus work: 5ab0d974-ef30-5474-9a5d-f3c0c2d71aba
DOI: 10.1101/2024.05.06.592854

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