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Dysregulated <i>MEG3</i> in Myotonic Dystrophy 1: nuclear retention, pathological role, and therapeutic correction by antisense conjugates

2025-06-21

Abstract excerpt

MEG3 , a long non-coding RNA (lncRNA), has been shown to play a critical role in regulating apoptosis. Its downregulation inhibits apoptosis in cancer cells, whereas its upregulation has been associated with cell death in both cardiovascular disease and, more recently, Alzheimer’s Disease. Here we show that MEG3 is upregulated in Myotonic Dystrophy 1 (DM1). Specifically, we show MEG3 upregulation by several-fold...

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Literature Corpus work
51526af8-8480-58b4-883c-cca20bce13c5
DOI
10.1101/2025.06.20.658327
Open publication

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Dysregulated <i>MEG3</i> in Myotonic Dystrophy 1: nuclear retention, pathological role, and therapeutic correction by antisense conjugatesDOI 10.1101/2025.06.20.658327
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