Article

Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species

2023-11-30

Abstract excerpt

Vertebrates differ greatly in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We compared transcriptomes of resting and LPS-exposed blood from six LPS-sensitive species (rabbit, pig, sheep, cow, chimpanzee, human) and four LPS-resilient species (mice, rats, baboon, rhesus), as well as plasma proteo...

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Literature Corpus work: 5a179a31-d792-5026-816b-3545f4994a14
DOI: 10.1101/2023.11.30.23299243

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