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Automated analysis of PD1 and PDL1 in lymph nodes and the microenvironment of transmissible tumors in Tasmanian devils

2022-11-01

Abstract excerpt

The wild Tasmanian devil ( Sarchophilus harrisii ) population has suffered a devastating decline due to two clonal transmissible cancers. Devil facial tumor 1 (DFT1) was first observed in 1996, followed by a second genetically distinct transmissible tumor, devil facial tumor 2 (DFT2), in 2014. DFT1/2 frequently metastasize, with lymph nodes being common metastatic sites. Downregulation of MHC-I by DFT1 cells is a...

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Identifiers and source

Literature Corpus work
0930b029-3f89-5e9a-a44e-414fa2a3a606
DOI
10.1101/2022.10.31.513798
Open publication

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Automated analysis of PD1 and PDL1 in lymph nodes and the microenvironment of transmissible tumors in Tasmanian devilsDOI 10.1101/2022.10.31.513798
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