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Article

CIITA induces expression of MHC-I and MHC-II in transmissible cancers

2021-07-14

Abstract excerpt

MHC-I and MHC-II molecules are critical components of antigen presentation and T cell immunity to pathogens and cancer. The two monoclonal transmissible devil facial tumours (DFT1, DFT2) exploit MHC-I pathways to overcome immunological anti-tumour and allogeneic barriers. This exploitation underpins the ongoing transmission of DFT cells across the wild Tasmanian devil population. We have previously shown that cons...

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Identifiers and source

Literature Corpus work
765a1c12-d9f6-5a0e-a437-241f9c1688e5
DOI
10.1101/2021.07.14.452299
Open publication

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CIITA induces expression of MHC-I and MHC-II in transmissible cancersDOI 10.1101/2021.07.14.452299
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