Article

The superoxide dismutase mimetic GC4419 enhances tumor killing when combined with stereotactic ablative radiation

2020-03-11

Abstract excerpt

The penta-aza macrocyclic manganese compound GC4419 is in phase 3 clinical trials as a modifier of mucositis in H&N cancer treated by radio-chemotherapy based upon its properties as a superoxide dismutase mimetic. In studies to address the potential for tumor radioprotection, a significant anti-tumor effect was identified in tumors generated from the non-small cell lung cancer (NSCLC) cell line H1299, when GC4419...

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Literature Corpus work: ad2b39b8-143a-5139-93e3-8c5513f9d928
DOI: 10.1101/2020.03.10.984443

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