Article

A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition

2025-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Angelman syndrome is a neurodevelopmental disorder characterized by severe motor and cognitive deficits. It is caused by the loss of the maternally inherited allele of the imprinted ubiquitin-protein ligase E3A ( UBE3A ) gene. Rodent models of Angelman syndrome do not fully recapitulate all the symptoms associated with the condition and are limited as a preclinical model for therapeutic develop...

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Literature Corpus work: 428568c2-20cb-5812-b1ca-c8fc54769211
DOI: 10.1101/2025.03.04.641215

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