Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition

21 Jul 2025

Abstract excerpt

Angelman syndrome is a neurodevelopmental disorder characterized by severe motor and cognitive deficits. It is caused by the loss of the maternally inherited allele of the imprinted ubiquitin-protein ligase E3A ( UBE3A ) gene. Rodent models of Angelman syndrome do not fully recapitulate all the symptoms associated with the condition and are limited as a preclinical model for therapeutic development. Here, we show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Syndromes and Imprinting
Share to Growth Hormone and Insulin-like Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40690672
DOI: 10.1073/pnas.2505152122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human conditionPMID 40690672Read ↗

A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human conditionSemantic proximity Read ↗

Cell-type-specific dysregulated gene expression in the frontal cortex of an Angelman syndrome pig modelSemantic proximity Read ↗

Angelman Syndrome: From Mouse Models to Therapy.Semantic proximity Read ↗

Angelman syndrome: a journey through the brainSemantic proximity Read ↗

Angelman syndrome: a review of the clinical and genetic aspects.Semantic proximity Read ↗

Stem cell models of Angelman syndromeSemantic proximity Read ↗

Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman SyndromeSemantic proximity Read ↗

Angelman Syndrome.Semantic proximity Read ↗

Elevated Delta Power in a Maternal <i>UBE3A</i> -Deletion Pig Model of Angelman SyndromeSemantic proximity Read ↗

Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome.Semantic proximity Read ↗

Angelman Syndrome: Identification and Management.Semantic proximity Read ↗

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.