Article

HMGB1 Neuroimmune Signaling and REST-G9a Gene Repression Contribute to Ethanol-induced Reversible Suppression of the Cholinergic Neuron Phenotype

2023-01-05

Abstract excerpt

<title>Abstract</title> <p>Adolescent binge drinking increases Toll-like receptor 4 (TLR4), receptor for advanced glycation end products (RAGE), the endogenous TLR4/RAGE agonist high-mobility group box 1 (HMGB1), and proinflammatory neuroimmune signaling in the adult basal forebrain in association with persistent reductions of basal forebrain cholinergic neurons (BFCNs). <italic>In vivo</italic> preclinical adole...

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Literature Corpus work: 59625867-01e6-515c-8643-b5fe15f6bb84
DOI: 10.21203/rs.3.rs-2267098/v1

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