Article
Alteration of gene expression by alcohol exposure at early neurulation.
BMC genomics - 21 Feb 2011
Zhou Feng C, Zhao Qianqian, Liu Yunlong, Goodlett Charles R, Liang Tiebing, McClintick Jeanette N, Edenberg Howard J, Li Lang
Abstract excerpt
BACKGROUND: We have previously demonstrated that alcohol exposure at early neurulation induces growth retardation, neural tube abnormalities, and alteration of DNA methylation. To explore the global gene expression changes which may underline these developmental defects, microarray analyses were performed in a whole embryo mouse culture model that allows control over alcohol and embryonic variables. RESULT:...
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